Health and longevity, can it be improved with supplements?

Longevity Supplement

A good quality longevity supplement can provide a strong foundation for health and longevity.

A healthy diet and exercise – when it comes to optimal wellbeing, those are the two things we read about all the time. It’s one of our best bets for producing a healthy body and mind, and to increasing longevity. But supplements also play a vital role in health and longevity, particularly if our diet is lacking in nutrients. As a result of observational studies, it’s frequently reported that people with a high intake of antioxidant vitamins, whether from diet or supplements, generally have a lower risk of major chronic diseases than people who are low consumers of antioxidant vitamins. The advice, then, is simple: eat plenty of whole, nutritious foods and exercise regularly.

But that’s not always easy. With our increasingly busy lives, good food and exercise doesn’t always play a starring role. Beyond a simple multivitamin, many of us wonder what else we can do to increase our health and longevity.

Here’s the good news. We can optimize our gut flora with fermented foods, or take a probiotic supplement to maintain healthy digestion, liver function and friendly bacteria levels. We can consume healthy fats, like Omega-3s (available in oily fish like salmon and sardines; and nuts and seeds, like flaxseed and walnuts,), or take fish or krill oil supplements. We can get plenty of sunlight to optimize our Vitamin D levels (essential for strong bones and a healthy immune system), or we can take a Vitamin D supplement.

Or to specifically target aging, we can take longevity supplements that help our body produce telomerase. Research shows that supporting healthy telomerase production in the body may help slow telomere shortening, which is critical to long life.

Telomeres (the protective tips on the ends of our chromosomes that get shorter each time our cells divide) are implicated in the aging process by both the number of short telomeres in the body and the rate at which short telomeres increase. Everyone has telomeres, but not everyone’s telomere lengths are the same, or shorten at the same pace. Telomeres naturally get shorter as we age, but not at the same rate for everyone. That can be because of genetics, but other factors point to free radical damage, chronic inflammation, smoking, obesity and excessive drinking. A rapid increase in shortened telomeres can lead to accelerated aging. Simply put, people who have longer telomeres live longer.

So yes, to support antiaging, general wellness and increased lifespan, certain supplements can help – in particular a longevity supplement that supports our body’s natural telomerase enzyme production to help maintain telomere length. Look for one that also contains antioxidants to protect against oxidative stress, a known accelerator of telomere shortening.

And don’t forget to indulge in healthy food and exercise.

How to Treat Knee Joint Pain

It might seem counterintuitive to exercise with sore joints (for example knee joint pain), but it’s just what the doctor ordered! Reduced activity results in reduced muscle strength, which compounds joint problems, whereas regular exercise strengthens the muscles around the joint and increases blood flow, two things that can minimise discomfort. You don’t have to run a marathon. Just a small amount of low intensity exercises will improve daily function, decrease stiffness and reduce pain. And all this without threatening the joints. Don’t make stiff joints your reason not to exercise. Instead, make it your reason to get moving.


It’s free, it’s simple, and you can do it anywhere and at any time. Plus it’s good for the heart. Cardiovascular exercises are just as important as strengthening exercises and range-of-motion (flexibility) exercises, to help keep weight down.

Even small changes in weight can have significant effects on knee pressure. According to a study that appeared in the Journal of Arthritis & Rheumatism in 2005, for every 1 lb of weight loss that occurs there is a resulting 4 lb reduction in knee joint load. It was also suggested that individuals who lost 10 lbs would be subject to a total of 48,000 less pounds of pressure for every mile walked.

One exercise to try? Walking backwards. The Journal of Exercise Physiology, April 2011, reported that walking backwards puts less strain and requires less range of motion from your knee joints, making it ideal for individuals with knee joint pain. And because backward walking eliminates the typical heel-strike to the ground (the toe contacts the ground first), it can lead to changes in pelvis alignment that help open up the facet joints in your spine, potentially alleviating pressure that may cause low back pain in some people.


If you find it difficult to exercise on land, try the swimming pool instead. Water cushions stiff, painful joints and enables individuals to exercise pain-free while simultaneously strengthening the muscles. The deeper the water, the more support and the less impact on joints. When immersed to the waist, your body bears just 50% of its weight; when immersed to chest height, the percentage is 25-35%. Up to the neck, it’s just 10%.

Exercising in water is a great cardiovascular workout, too. Swim laps, try walking in water, or take an aqua-aerobics class. As for on land, try walking backwards. A study in Japan showed that walking backwards in water engaged more muscles than if walking forwards, while boosting the heart rate.

Using weights

The stronger your muscles, the less strain there is on your joints. Strong muscles help keep weak joints stable and protect them against further damage and discomfort. Start slowly and increase the intensity gradually. Small dumbbells, stretch bands or leg or arm weights are ideal to start with.

Knee extensions using ankle weights, for example, help target the quadricep muscles in the front of the thigh, which helps strengthen weak knees. It’s a two-fold process though. This particular exercise should be done in conjunction with knee curls, as the muscles targeted in these two exercises—the front thigh muscles and the hamstrings—work together when you walk, stand and climb.

To perform a knee extension, put on ankle weights and sit in an armless chair, resting your arms on the side of your thighs. With your toes pointing forwards and your foot flexed, slowly lift your right leg to a count of two, extending your leg until your knee is straight. Pause, then lower your foot to the ground, to a count of four. Repeat this exercise 10 times with your right leg, then 10 times with your left leg for one set.

For the knee curl exercise, stand behind a chair with your feet shoulder-width apart. Keeping your foot flexed, bend your right leg and bring your heel up towards your buttocks, to a count of two. Pause, then lower your foot back to the ground, to a count of four. Repeat 10 times with your right leg and 10 times with your left leg for one set.


Stretching reduces the risk of muscle atrophy. If we sit all day, for example, our buttocks muscles become imbalanced and our hamstrings and hip adductors become overworked to compensate, and that results in compressive force on our knee joints.

Hamstring stretches

Your hamstrings support the hip and knee joints, so it’s important to keep these muscles strong and flexible. Find a chair or other object that is about 50cm high. Rest one foot on the chair with the knee slightly bent. Lean forwards and down, keeping your back straight, until you feel a stretch in the middle of the hamstrings. Hold for 30 seconds. Repeat with other leg.

Hamstring stretches

Back stretches

Sacroiliac joint pain can affect the back, the hip, and even down the leg. Regularly stretching the back muscles can keep the hips, buttocks and back relaxed while restoring a normal range of motion.

For a simple press-up, lie on your front and, with your pelvis remaining in contact with the floor, press up on your hands. Keep the lower back and buttocks relaxed for a gentle stretch. Hold for 5 seconds initially, then gradually work up to 30 seconds per repetition. Aim to complete 10 repetitions.

Back Stretch


Shrugging your shoulders can help keep them loose. It’s simple but very effective for tight shoulders. Repeat 20 times. You can progress by reaching your arms up and stretching them as you can comfortably go.


Exercising the hip joints increases flexibility and increases mobility. For a simple exercise, sit in a chair and, holding onto the seat, lift each leg like you’re walking. The higher you raise your leg, the deeper the stretch will be.

For a more advanced exercise, get on your hands and knees. Extend one leg out behind you and hold for five seconds. Repeat five times with each leg.

Hip Exercises


In combination with these exercises a supplement that targets joint pain is highly beneficial. A high-quality joint supplement like Puraz PRO-d works specifically to restore the substances needed in your body for healthy joints and an active lifestyle. Be proactive – exercise regularly and take a nutritional supplement to get on top of your joint pain.

Matrixyl supplements – so many to choose from

Matrixyl Skincare

The right combination of Matrixyl and other peptides is a powerful anti-aging treatment. But finding an effective product can be a challenge.

What’s best for me? That’s the $64,000 question. Consumers are faced with so many choices of anti-aging skincare products that choosing the ingredient that’s best for you can be challenging. If you’ve decided that Matrixyl is the right choice for you – and you’d be in good company – then which Matrixyl supplement should you choose?

Just as there are different herb blends for specific tea formulas, there are several different Matrixyl formulas, each one containing a different blend of peptides and other ingredients, some more effective than others. Peptides are amino acids that make up the proteins in the skin, and those used in skincare products penetrate the skin cells and stimulate the production of collagen.

Matrixyl is one of the most powerful peptides used in high-quality, anti-wrinkle skincare products, but it becomes even more effective when combined with other peptides, like Argireline, for example. Studies show that Argireline has a mild Botox-like effect on the skin, inhibiting the release of neurotransmitters and relaxing the facial muscles, thus reducing wrinkles. Skin topography analyses have proven the ingredient to reduce the depth of wrinkles by 27% to 60% when applied via high-end topical creams.

Matrixyl, itself, has impressive credentials too. During a six-month study it was found that application through a product such as Puraz COMPLETE, which also contains Argireline, reduced wrinkle surface by 68% and line density by 47%.

So how do Matrixyl supplements work in skin creams?

Matrixyl stimulates the ‘matrix’ layer of the skin. It promotes the growth of collagen as well as other proteins, such as elastin and glucosaminoglycans, by mimicking nature’s own tissue regenerating process, sending a message to the skin to synthesize the material necessary for padding and firming. The active molecule, Micro-collagen, a powerful peptide, penetrates the skin, reaching the fibroblast cells. This is especially helpful because, as we age, fibroblasts slowly lose the capacity for natural collagen production. Loss of collagen is what leads to thinning skin and fine lines and wrinkles. Matrixyl helps to counteract this natural aging process.

Matrixyl, along with Argireline, is an exceptionally powerful anti-aging supplement, but for those prone to dry skin, the addition of hyaluronic acid will give you the ultimate in skincare. Hyaluronic acid is a natural moisturising compound that absorbs up to 1000 times its own weight in moisture, providing intensive hydration to help the skin look younger. As with collagen, hyaluronic acid is something we lose as we age.

There is not much point adding a whole lot of other ingredients to anti-aging skincare products because Matrixyl is one of the only ingredients to stimulate collagen synthesis. Dermatologists and users alike have confirmed this amazing anti-wrinkle effect.

For a high-end, high-quality product, look for a Matrixyl supplement that contains Matrixyl, Argireline and hyaluronic acid.

Buy Matrixyl supplements

Why beauty therapists are pro collagen

Pro Collagen

Over time, our skin’s collagen levels start to decline; there is a drop in our body’s natural collagen production and consequently an increase in degradation.

There are any number of treatments your beauty therapist may recommend for skin rejuvenation but one that’s often recommended is collagen supplementation – a non-invasive, all-natural solution for smoother, firmer looking skin.

Collagen is part of the matrix that helps ‘hold’ our skin together. It keeps it firm and plump. However, over time collagen levels start to decline; there is a drop in our body’s natural collagen production and consequently an increase in degradation. Most people know when skin loses collagen we develop wrinkles.

Collagen-based skincare products are instrumental in restoring strength and resilience to our skin. They help preserve our collagen and even boost its production. But not all collagen products work. Their effectiveness depends on how you’re introducing the collagen into your body. Creams won’t work because the collagen molecules are too large to penetrate the skin. Even if the molecules were made small enough to be absorbed, they cannot bind with the collagen existing in skin.

Collagen supplements, however, are a different story. Scientists have proven they are effective at renewing collagen levels. But the collagen specifications are important. In order for collagen supplements to be effective, they have to contain the right type of collagen.

Interestingly, there are more than 25 different types of collagen in the body, all of which perform a different function. Collagen XXII, for example, is specific to tissue junctions such as the myotendinous junction (MTJ). The MTJ is a specialised anatomical region that connects skeletal muscle to tendon. This type of collagen is beneficial for those particular areas but not so much for the skin. On the other hand, Collagen I and III are both abundant in skin, so they’re both helpful for skin rejuvenation.

What your skin needs, then, is a blend of the right kind of collagen, one that’s been specifically formulated to help boost the levels of collagen, elastin and hydration in your skin – something like Puraz 100% Collagen capsules, which have been developed over many years and contain a formula of specific collagen types that have been proven to replenish lost collagen to the skin, as well as the hair and nails. Beauty therapists will look to this type of collagen supplement because they have been found to substantially improve the appearance of fine lines and wrinkles. At the same time, collagen synthesis is stimulated.

Best results come with continuous use. But the science backs it up. Taken regularly, collagen supplements produce smoother skin and reduce the depth of lines, wrinkles and sagging.

How to purchase collagen in capsule form

How do dietary supplements work?

Dietary Supplements

As today’s modern diet is often lacking in essential nutrients, dietary supplements are becoming increasingly necessary.

Dietary supplements are often part of an individual’s health regimen. With today’s modern diet often lacking in essential nutrients, supplements are a convenient way to ensure we receive adequate levels of vitamins and minerals, amino acids and enzymes, or herbs or other botanicals and their constituents.

While supplementation can target nutrient deficiencies, certain dietary supplements can modulate the body’s biochemical processes to decrease inflammation, enhance digestion, or boost metabolism, among other things.

Some supplements are designed to target one particular aspect of your health (like joint pain, for example), while others are intended for overall health and wellbeing (like a multi-vitamin). Vitamin A supports vision and bone growth, for instance, and Vitamin E supports the immune system. Calcium is needed to promote bone health and reduce bone loss, but we also need Vitamin D to help absorb calcium. While a small amount of Vitamin D comes from our food, our bodies typically make Vitamin D from sunlight. But as many of us live and work inside, we often don’t get enough of it.

Folic acid is another example. It’s important for cell growth and reproduction and for ensuring healthy development of babies in early pregnancy. It decreases the risk of birth defects, which is why pregnant women or those women wanting to get pregnant are often advised to take folic acid supplementation.

Fish oil supplements provide omega-3 fatty acids that may help reduce the risk of coronary heart disease as well as type 2 diabetes. They can also be useful at relieving joint tenderness and morning stiffness. As most diseases seem to be related to some sort of inflammatory process, omega-3s can help to tone this down and reduce the symptoms of diseases such as arthritis. But as well, children with ADHD may have lower levels of omega-3s. A lack of omega-3s has also been linked with the incidence of asthma, diabetes and depression.

Certain botanical extracts have benefits too, some simply contributing to a healthy diet and others helping with the reduction of symptoms of various illnesses. A combination of botanicals and antioxidants may assist high cholesterol, for example. Citrus bioflavonoids and tocotrienols from sustainable palm oil, in combination with policosanols from sugar cane, theaflavins from black tea extract, phytosterols derived from soy, and curcuminoids from turmeric, make the product CL6 one of the most effective and powerful natural cholesterol support products available today.

But while dietary supplements do have their benefits, it’s important to note that they are not drugs (medication) and they do not work like drugs. They are intended to supplement the diet only, to help increase the total dietary intake of a certain substance. They are not intended to treat or cure diseases. Prescription drugs are designed to block or interfere with normal function, and effectively mitigate, prevent or cure diseases.

You need to be careful when choosing your supplements, too. Some manufacturers promise all sorts of benefits from their supplements that aren’t entirely accurate. It can be difficult to know which supplements offer genuine health benefits and actually provide what the label says. It’s important to choose from a reputable manufacturer that offers high-quality products with consistency of dose, and no fillers, additives or colourings.

For example, companies like Puraz Health are extremely diligent in the choice of its raw materials, and their quality and effectiveness. More importantly, the results of all Puraz dietary supplements are backed by good science. It doesn’t matter how much science backs up a particular ingredient, if the potency or quality in a certain product is inferior, or the ingredients are contaminated, the supplement, no matter how many you take, will simply not be effective.

Joint pain remedies

Joint Pain

The most effective joint pain remedies target long term health.

Joint disease is a painful and degenerative condition that’s marked by inflammation, stiffness and discomfort. Age, undue pressure on the joints and wear and tear causes the protective cartilage to wear out.

Anti-inflammatory medications can provide some relief, but the most effective joint pain remedies target long-term health. The following remedies go a long way to providing long-term joint comfort.

Weight loss

The more weight that’s on a joint, the more stressed the joint becomes, especially the weight-bearing joints such as knees and hips. For every pound of excess weight on your body, an extra 4 pounds of pressure is exerted on the joints. If you’re 14lb (1 stone/6.3 kilos) overweight, for example, that’s an extra 56lb (4 stone/25 kilos) of pressure exerted on your joints.

But that’s not all. The fat that comes from excess weight is active tissue, as opposed to inert tissue, and releases certain chemicals that promote inflammation.

Losing excess weight relieves pressure on the joint, decreases pain and prevents further wear and tear.


When you’re experiencing pain, exercise is probably the last thing on your mind. But exercise helps keep the joints flexible and prevent muscle weakness and loss. When we’re inactive, the synovial fluid in our joints becomes gel-like; once we start moving, the liquid becomes more viscous, doing a better job at lubricating our joints and maintaining flexibility.

Consume more fatty acids

Omega-3 fatty acids are powerful anti-inflammatory agents. They help suppress joint inflammation and prevent further damage. Consuming more Omega-3 fatty acids can also help lubricate the joints and allow you to move more freely.

Another benefit of Omega-3s is weight loss. Fats in the diet take longer to digest and keep you feeling full for longer. Consuming more foods with Omega-3 fatty acids – the good fats – has the same effect and a reduced appetite may result.

Our bodies cannot make fatty acids on their own so we need to consume them through diet or supplementation. A high-quality fish oil, like Puraz Krill Oil, is ideal. Foods high in Omega-3s include:

  • Oily fish, such as salmon, tuna, sardines, mackerel and herring
  • Flax seeds
  • Chia seeds
  • Walnuts
  • Fresh basil
  • Brussels sprouts
  • Spinach
  • Wild rice
Eat turmeric

Turmeric, the yellow spice frequently used in Indian cooking, contains curcumin, a compound that has anti-inflammatory properties. It acts as a scavenger of nitric oxide and inhibits COX-2, a pro-inflammatory substance. Studies suggest it is effective at inhibiting joint inflammation, decreasing pain and increasing comfort levels. Add turmeric to your cooking, or try a turmeric and ginger tea (ginger also has anti-inflammatory properties).

Supplement with collagen

As we get older, our collagen levels decline, causing our cartilage to deteriorate (collagen is the main building block of cartilage). Cartilage provides the ideal shock-absorbing capacity for our joints, ensuring our joint comfort.

One of the most effective joint pain remedies is a collagen supplement like Puraz PRO-d. The collagen from PRO-d distributes to the cartilage, restoring collagen and helping that cartilage regenerate. It gets to the root of the problem to provide optimum long-term joint health.

Topical remedies

While putting a long-term plan into action, a topical joint cream can assist in relieving pain immediately. Puraz Inflamox, for example, is a potent, all-natural cream (active ingredients include capsaicin, arnica and ginger) that relieves painful joints. It’s absorbed through the skin, right at the target area, so it’s especially useful for people who can’t take oral NSAIDs (non-steroidal anti-inflammatory drugs) because of stomach or heart risk factors.

Any one of these joint pain remedies is a great start to ensuring joint health and comfort.

Food for me or my skin?

Skin Food

Nutritionally dense foods can increase our vitality, protect us from diseases and prevent premature aging.

Take a look at why you eat. The obvious reason is because you’re hungry, but it makes much more sense to eat for wellbeing. The types of food we put in our body can affect our heath. Nutritionally dense foods – pure, whole foods free from additives and preservatives – can increase our vitality, protect us from diseases and prevent premature aging. Such is the power of food.

But which foods should you eat?

Antioxidant-rich foods

Antioxidants play a crucial role in optimal health. They can control how fast you age by combating free radicals, which are linked to many diseases. Antioxidants also keep the skin cells healthy and protect collagen and elastin from deteriorating, keeping your skin more youthful for longer.
Load up on antioxidant-rich foods such as berries, apples, plums, beans, kale and broccoli.


Your body needs both macro- and trace minerals to grow, develop and function properly. They are also essential for healthy skin. Zinc, for example, is fundamental to a healthy immune system, but it also has an anti-inflammatory effect on the skin. Selenium, while playing a vital role in the fight against cancer and heart disease, also reduces aging caused by oxidation. It also helps heal the skin. Iron is another mineral that’s great for aiding skin repair.
Get more zinc in your diet by eating beef, lamb, crab, oysters, poultry, fortified cereals and pumpkin seeds.
To get more selenium, eat fish, poultry, brewer’s yeast, wheat germ, whole grains, sunflower seeds and Brazil nuts. Iron can be obtained from lentils, soybeans, spinach, red meats and liver.


Omega-3 fatty acids are essential for heart health and brain function. They also decrease inflammation in the body and skin. Chronic inflammation, which is invisible to the eye, can destroy collagen and elastin, causing premature aging. It can also cause life-threatening diseases.
Omega-3 fatty acids can be found in fatty fish, krill oil, flaxseeds, soybeans, walnuts and canola oil.

Amino acids

Amino acids are the building blocks of protein and essential for growth, repair and maintenance. Without them our bodies would have trouble functioning. They are also essential for the maintenance and repair of skin tissue. They help build collagen, supplying nutrients to nourish the skin and keeping it smooth and elastic. They also help improve the skin’s ability to stay hydrated.
To get more amino acids, eat poultry, fish, lean meats, eggs, legumes, seaweed, seeds (sunflower, pumpkin, chia, hemp, etc) and nuts.

A high quality collagen supplement is another superb skin food, providing amino acids for skin repair and health.

What not to eat

It’s probably obvious. Avoid highly processed and sugary foods. Eating too much of these foods raises your blood sugar levels and your insulin. It also triggers low-grade, chronic inflammation.

A joint formula that will make you want to go for a run!

Knee Pain Remedy

Joint pain is often the result of cartilage degeneration. An advanced collagen joint formula will target the root of the problem and begin to rebuild cartilage.

You can’t run. You can’t jump. You can’t even bend down to pick something up without flinching. You need help, because your joints are in a bad way.

What the heck is going on?

More than likely it’s simple wear and tear (everybody experiences joint wear and tear, but for some it’s more prominent than others). Over time, our joints, like other body parts, wear out. The connective tissue in our joints begins to deteriorate, and that causes bone to rub on bone. When that happens we experience pain and discomfort.

The pain is often worse after certain activities or when we put weight on the joint. You may not even think about it, but we put enormous pressure on our joints every day – running, lifting heavy loads, constantly bending and kneeling, and exercising and playing sports. Even just walking up stairs, the pressure across the knee joint is four times our body weight.

The outcome? We start to avoid pain-producing activities, and that affects our lives. We miss out on the things we used to take part in and enjoy. We miss out on life.

If we experience knee pain, or any other joint paint, we should do something about it. Pain means there’s something wrong. If we ignore it, any short-term inflammation may turn into long-term tissue degeneration. We need to seek out a knee pain remedy, or joint formula, that fixes the root of the problem.

Typically, that’s cartilage degeneration. In order to maintain and regenerate cartilage – in order to start running, jumping and bending down again without discomfort – we need to target collagen regeneration, which in turn helps rebuild damaged cartilage. Without collagen, we cannot maintain healthy cartilage.

Collagen is a resilient protein that forms the structure and strength of our bones and cartilage, as well as other connective tissues. Just as certain minerals are necessary for the development of strong bones, additional nutrients support the synthesis of collagen for joints and cartilage. A joint pain treatment, or collagen joint supplement, helps boost collagen production in our bodies. More specifically, it provides collagen peptides to supply the amino acids that are needed to build new collagen.

If your activities are hampered by joint discomfort, an advanced collagen joint formula will promote a lifelong change. Before long, it may even make you want to go for a run.

Treating arthritis in dogs easily

Arthritis in dogs

Just like in humans, arthritis and joint problems in animals can impact greatly on quality of life.

Like humans, dog’s knees and hips can become creaky with age. Osteoarthritis affects 20% of dogs over 1 year of age and more than 90% of dogs over 5 years, causing pain and progressive breakdown of the articular cartilage.1

Symptoms of arthritis in dogs (and cats!) include:
  • Limping and/or reluctance to exercise
  • Diminished playfulness
  • Irritability when touched
  • Difficulty doing things that were once easy, such as getting into a car or onto the couch
  • Overgrooming and self-biting

Although osteoarthritis is considered incurable, nutrition and lifestyle can play a role in management of symptoms, particularly if commenced earlier in the disease process.13 Dietary supplementation can provide the substrates for cartilage production and inhibit the enzymes and free radicals that cause cartilage damage.

Weightloss and Diet

Being overweight places a burden on the joints, and a successful weightloss intervention can reduce or eliminate the need for painkilling drugs1. Anecdotal evidence suggests that some dogs do better on a grain-free diet. This makes sense, as dogs are primarily carnivores, however there have been no studies to date which examine the theory. Consult with your vet about the best diet for your dog’s health and weightloss.

Petifort Pet Joint Supplement

Petifort is a leading joint supplement for pets, produced by Puraz Health. It helps repair damaged cartilage, lubricate joints and promote your pet’s bone health. The formula is designed to taste good and can be simply sprinkled over your pet’s food to the required dosage. Its active ingredients work to restore your animal’s mobility and quality of life.

Buying pet joint supplements online

Petifort Active Ingredients:
Collagen Hydrolysate

Collagen is the main component of cartilage. Collagen hydrolysate has a unique profile that is high in anti-inflammatory amino acids. Animal studies using radioactively labelled collagen have shown that oral intake leads to accumulation in cartilage tissue2 where it functions to synthesise the cartilage matrix.3 Numerous studies show a positive effect on arthritis symptoms, collagen maintenance and bone health in humans3 and animals. A 2010 double-blind, placebo controlled study showed that 10g daily collagen hydrolysate for 8 weeks significantly improved stiffness, lameness and activity levels in 15 arthritic dogs.4

Green Lipped Mussel (GLM)

A multitude of studies show that New Zealand Green Lipped Mussel (perna canaliculus) offers benefits in the management of joint pain syndromes in humans5,6 and animals.7 GLM powder is rich is anti-inflammatory Omega 3 fatty acids, vitamins, minerals, amino acids, glucosamine, chondroitin and glycosaminoglycans, which act a lubricant and shock absorber within the joint. Randomised, controlled trials and field trials in dogs have shown improvements in total arthritic score of up to 30%, with improved joint pain and joint swelling,5-8,9 as well as improved veterinary-assessed mobility.10

Vitamin C

Vitamin C is necessary for cartilage formation and maintenance and also acts as an antioxidant, reducing cartilage damage by free-radicals. Although dogs can produce their own vitamin C, this ability diminishes as they age.

Hyaluronic Acid

Hyaluronic Acid is a component of cartilage which is responsible for its resilience and ability to withstand daily wear and tear. Studies in rats and dogs have shown that oral intake of hyaluronic acid resulted in uptake and accumulation in the connective tissues.11


Boron is a trace element, the global concentration of which varies widely and correlates with incidence of arthritis. Arthritic bone contains less boron than normal bone.5


Manganese has an important role in bone and cartilage development. It activates the glycotransferase enzymes which are necessary for the formation of polysaccharides and glycoproteins, including glycosaminoglycans. A deficiency of manganese limits the rate of glycosaminoglycan synthesis, even when the substrate glucosamine is present.12

Hopefully, the above will give you some ideas for dietary adjustments that might put a spring back in your best friend’s step. Nobody wants to feel creaky!

Please click here for more info on Petifort and arthritis relief for cats and dogs

Author Bio:

Sara Lake
Sara Lake is a Christchurch (New Zealand) based nutritionist, food blogger and MSc student of human nutrition at Massey University.


1. Servet et al. (2006). Dietary intervention can improve clinical signs in osteoarthritic dogs. The Journal of Nutrition 136, p. 1995A-1997S.
2. Oesser, S., Adam, M., Babel, W., & Seifert, J. (1999). Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). The Journal of Nutrition, 129(July), 1891–1895.
3. Moskowitz, R. (2000). Role of Collagen Hydrolysate in Bone and Joint Disease. Seminars in Arthritis and Rheumatism, 30(2), 87-99.
4. Beynen, a C. (2010). Oral administration of gelatin hydrosylate reduces clinical signs of canine osteoarthritis in a double‐blind, placebo‐controlled trial. American Journal of Animal and Veterinary Sciences, 5(2), 102–106.
5. Ameye, L. G., & Chee, W. S. S. (2006). Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Research & Therapy, 8(4), R127. doi:10.1186/ar2016
6. Cobb, C. S., & Ernst, E. (2006). Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: The effectiveness of the New Zealand green-lipped mussel Perna canaliculus. Clinical Rheumatology, 25, 275–284. doi:10.1007/s10067-005-0001-8
7. Bierer, T. L., & Bui, L. M. (2002). Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus). The Journal of Nutrition, 132, 1634S–6S.
8. Bui, L. M., & Bierer, R. L. (2001). Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Veterinary Therapeutics : Research in Applied Veterinary Medicine, 2, 101–111.
9. Servet, E., Biourge, V., & Marniquet, P. (2006). The WALTHAM International Nutritional Sciences Symposia Dietary Intervention Can Improve Clinical Signs in Osteoarthritic Dogs 1 – 3, 1995–1997.
10. Hielm-Björkman, A., Tulamo, R. M., Salonen, H., & Raekallio, M. (2009). Evaluating complementary therapies for canine osteoarthritis part I: Green-lipped mussel (Perna canaliculus). Evidence-Based Complementary and Alternative Medicine, 6(October 2007), 365–373.
11. Schauss, A., Balogh, L., Polyak, A., Mathe, D., Kiraly, R., Gyozo, J., Yao, T. & Bucci, L. (2008). Absorption, distribution, excretion and tissue uptake of 99mtechnetium labelled hyaluronan after single oral doses in rats and beagle dogs. The FASEB Journal, 22 (Meeting Abstract).
12. Messonnier, S (2001). Natural Health Bible for Dogs and Cats. Three Rivers: New York.
13. Sense, D. M., Natural, C., & Food, P. A helpful guide to feeding your pets a raw food, species-appropriate diet for cats and dogs.

T5 and Telomere Science

Telomere Science

Telomere science is helping keep cells is optimal condition.

It may not seem like it, but when you buy a health product, you are purchasing the end result of months, or even years, of research and development. Every ingredient is there for a reason.

The aim with T5 was to find natural products which peer-reviewed articles suggested may have a positive effect on the telomere in healthy cells The telomere is a sort of biological clock. It is attached to the chromosomal DNA and shortens every time healthy cells divide. The shortening telomere eventually reaches the irreversible point of ‘cellular senescence’, after which the cell no longer divides or functions in the same way as a young cell. In particular we sought products which affect activity and levels of telomerase. Often referred to as ‘the fountain of youth’[1], telomerase is an enzyme responsible for transcribing the telomere onto the end of the chromosome and for maintaining the length of it.

After reading a fat stack of literature, including studies which addressed oral absorption, dosages and safety, we settled on Astragalus extract, Baicalin, Glutathione, Selenium and an antioxidant mix as the most effective combination.

Astragalus Extract

Astragulus membranaceous is a fundamental herb of Chinese medicine. It contains two powerful and supremely expensive ‘small molecule selective telomerase activators’ known as Astragaloside IV and Cycloastragenol. The levels of Cycloastragenol in T5 are miniscule, however some Astragaloside IV is converted to it during digestion[2]. In-vitro studies have shown that Astragalus extracts can selectively increase telomerase activity by up to 3.3 times[3], slow telomere loss in immune cells and upregulate the level of telomerase in skin cells through increasing telomerase production[4]. Animal studies have shown increased telomere length and decrease in various signs of aging in old mice[5]. The effect of extracts on cells was cumulative, with five months exposure having a greater effect than 7 days[4]. A human trial showed that after 12 months on a protocol which included Astragalus extract, cells begin to model a more youthful configuration and show fewer short telomeres than those from humans that were not on the protocol[6]. Astragaloside IV and Cycloastragenol equally inhibit oxidative stress[7] (free-radical damage) which affects the telomere more than other parts of the chromosome[8].

Baicalin and Telomere Science

Baicalin is a flavone extracted from the medicinal herb Scutellaria baicalensis. In-vitro, baicalin protects skin cells from the telomere damage usually inflicted by Ultraviolet A radiation[9]An inhibitory effect of baicalin in cells and skin exposed to UVB radiation has also been seen[10,11]. Along with oxidative damage, UV radiation is a major cause of visible skin aging (‘photoaging’). Usefully, baicalin is also an antioxidant. Although most studies have been in-vitro, other studies have shown both that baicalin is absorbed in the colon (that is, not destroyed by digestion[12] and that certain metabolic products of oral ingestion are reproduced when pre-digested baicalin is applied directly to intestinal cells[13]. In other words, there are strong indications that baicalin is effective when taken orally.


Glutathione is synthesised by every human cell and functions as the body’s master antioxidant, mopping up the telomere-damaging free radicals and peroxides that result from environmental exposure to toxins and from normal metabolism.  Telomere length and integrity are strongly related to oxidative stress. Glutathione also helps regenerate other antioxidants, including vitamins C and E and regulates telomerase[14]. Research has shown that the levels of active glutathione in the cell decrease under conditions of oxidative stress, leading to telomere damage[15,16].  Oral glutathione intake has recently been shown to effectively boost cellular glutathione levels in humans[17].

Antioxidants and Selenium

Having already established that oxidative stress is a major factor in telomere damage, we decided to include a broad range antioxidant in T5. Although research is limited, one cross-sectional analysis reported that telomeres were 5.1% longer in women using a mixed antioxidant multi daily and that higher intakes of vitamins C and E from food are associated with telomere length[18]. Selenium, cellular levels of which decrease with age, is a potent antioxidant that has been shown to increase telomerase activity and genetic expression of its sub-unit hTERT in rat and human liver cells[19,20].

What Else?

Of course, not everything can go into a supplement! During the research process we also discovered that moderate exercise and a diet high in fruits and vegetables are telomere protective, while smoking and alcohol consumption are telomere unfriendly. Ultimately it comes down to looking after your telomeres, so that they can look after you.

Author Bio:

Sara Lake
Sara Lake is a Christchurch (New Zealand) based nutritionist, food blogger and MSc student of human nutrition at Massey University.


1.            University of Copenhagen. ‘Fountain of youth’ telomerase: Scientists successfully map enzyme that has rejuvenating effect on cells. 2013.

2.            Zhou, R.N., et al., Pharmacokinetic evidence on the contribution of intestinal bacterial conversion to beneficial effects of astragaloside IV, a marker compound of astragali radix, in traditional oral use of the herb. Drug metabolism and pharmacokinetics, 2012. 27(6): p. 586-97.

3.            Molgora, B., Bateman, R., Sweeney, G., Finger, D., Dimler, T., Effros, R., Vlenzuela, H., Functional Assessment of Pharmacological Telomerase Activators in Human T Cells. Cells, 2013. 2: p. 57-66.

4.            Fauce, S.R., et al., Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8(+) T Lymphocytes. Journal of Immunology, 2008. 181(10): p. 7400-7406.

5.            Bernardes de Jesus, B., et al., The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging cell, 2011. 10(4): p. 604-21.

6.            Harley, C., Liu, W., Blasco, M, Vera, E., Andrews, WH., Briggs, LA., Raffaele, JM., A natural product telomerase activator as part of a health maintenance program. Rejuvenation Research, 2011. 14(1): p. 45-56.

7.            Zhao, Y., et al., Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. Journal of ethnopharmacology, 2015. 169: p. 210-8.

8.            von Zglinicki, T., Oxidative stress shortens telomeres. Trends in biochemical sciences, 2002. 27(7): p. 339-44.

9.            Min, W., et al., Effects of baicalin on ultraviolet A-induced telomere damage in cultured human primary fibroblasts. Zhonghua Pifuke Zazhi, 2011. 44(9): p. 639-642.

10.         Min, W., et al., Inhibitory effects of Baicalin on ultraviolet B-induced photo-damage in keratinocyte cell line. The American journal of Chinese medicine, 2008. 36(4): p. 745-60.

11.         Bing-Rong, Z., et al., Protective effect of the Baicalin against DNA damage induced by ultraviolet B irradiation to mouse epidermis. Photodermatology, photoimmunology & photomedicine, 2008. 24(4): p. 175-82.

12.         Li, L.J., J. Li, and H.W. Lou, [Study on in situ intestinal absorption of baicalin contained in Tiangou Jiangya capsules]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013. 38(6): p. 894-8.

13.         Morisaki, T., et al., Baicalin pharmacokinetic profile of absorption process using novel in-vitro model: cytochrome P450 3A4-induced Caco-2 cell monolayers combined with rat intestinal rinse fluids. Journal of Pharmacy and Pharmacology, 2013. 65(10): p. 1526-1535.

14.         Pallardo, F.V., et al., Role of nuclear glutathione as a key regulator of cell proliferation. Molecular aspects of medicine, 2009. 30(1-2): p. 77-85.

15.         Kurz, D.J., et al., Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. Journal of cell science, 2004. 117(Pt 11): p. 2417-26.

16.         Richter, T. and T. von Zglinicki, A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Experimental gerontology, 2007. 42(11): p. 1039-1042.

17.         Richie, J.P., Jr., et al., Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European journal of nutrition, 2015. 54(2): p. 251-63.

18.         Xu, Q., et al., Multivitamin use and telomere length in women. American Journal of Clinical Nutrition, 2009. 89(6): p. 1857-1863.

19.         Yu, R.A., et al., Telomerase activity and telomerase reverse transcriptase expression induced by selenium in rat hepatocytes. Biomedical and environmental sciences : BES, 2009. 22(4): p. 311-7.

20.         Liu, Q., et al., Effects of trace elements on the telomere lengths of hepatocytes L-02 and hepatoma cells SMMC-7721. Biological trace element research, 2004. 100(3): p. 215-27.